During the systems development life cycle, when should security and quality be addressed for an application?

1- During the systems development life cycle, when should security and quality be addressed for an application?
2- What is a misuse case and how should it be used during application development?
3- What is input cleansing and why is it so critical in secure programming?
4- What is an Application Guide and how can it aid in developing and testing secure applications?

please include questions in the doc.

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