Create an original model of hemoglobin that shows how oxygen is carried by the molecule.n1. Label the following components in your model:n• subunitsn• heme groupsn• iron atomsn• oxygen moleculesnnNote: You can use ribbon, pipe cleaners, or similar materials in your model.nnNote: Take a picture of your completed model as evidence that you created it. You can include the picture as part of your presentation or report, or you can upload it in Taskstream as a separate attachment.nn2. Explain three major differences between the oxygenated and deoxygenated states of hemoglobin.n3. Explain how pH impacts the binding and release of oxygen by hemoglobin.na. Create an original graph that demonstrates the relationship between hemoglobin’s oxygen binding and oxygen concentration at different pH levels.n4. Create an original diagram that compares the biochemical (protein) structure of hemoglobin to myoglobin.na. Label each of the following components in the diagram from part A4 to show the comparison:n• subunitsn• heme groupsn• iron atomsn• oxygen moleculesnnNote: Take a picture of your completed diagrams as evidence that you created it. You can include the picture as part of your presentation or report, or you can upload it in TaskStream as a separate attachment.nnB. Demonstrate your understanding of sickle cell anemia by doing the following:n1. Create a diagram that demonstrates the molecular difference (amino acid change) between normal and sickle forms of hemoglobin.nnNote: Take a picture of your completed diagram. You can include the picture as part of your presentation or report, or you can upload it in Taskstream as a separate attachment.nn2. Create a diagram that demonstrates the difference between normal and sickle red blood cells at the cellular level.nnNote: Take a picture of your completed diagram. You can include the picture as part of your presentation or report, or you can upload it in TaskStream as a separate attachment.nn3. Compare how diseased cells differ from normal red blood cells in their capacity to transport and deliver oxygen.n4. Explain the molecular inheritance of sickle cell anemia by doing the following:na. Identify the type of inheritance seen in sickle cell anemia.nb. Describe the outcomes for the offspring of two carrier parents (genotype and phenotype and percentages of each).nc. Create a diagram, or series of simple diagrams, that demonstrates of how sickle cell genes are inherited (e.g., pedigree charts, Punnett squares).nnNote: Take a picture of your completed diagram.
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