The impact of genetics on lung disease is an area of immense interest, as researchers attempt to identify factors that cause some people, and not others, to undergo accelerated rates of decline in FEV1.0.
Questions
1. Briefly describe the UK Biobank in terms of its remit, governance, and data accessibility.
2. List and cite the web addresses of 5 other Biobanks, including at least one in Australia.
3. Extract data on FEV1.0 and FVC from the available data in the UK Biobank. Construct a table with the UK Biobank cohort data together with data from your own cohort (as provided in the practical class excel spreadsheet results on LMS).
4. An adaptation of the survey questionnaire from the UK Biobank was used to determine the physical activity of your peer group. The collated data is available on LMS. Extract and present the data on exercise patterns of the UK Biobank volunteers that is most relevant to the class survey data that you have been provided. Write a commentary on the patterns of exercise, comparing the levels of physical activity to the results of the physical activity survey of your peer group.
5. The following questions relate to the Nottingham group’s research on urokinase plasminogen activator receptor (uPAR) and lung function decline.
a. Write a brief overview of the roles of uPAR, including a description of how this receptor is activated. Support your discussion by citing TWO review articles that you found to be useful in preparing your response to this question.
b. What evidence supports there being an impact of uPAR on the decline in lung function? Provide THREE original articles to support your discussion.
c. Describe how access to the UK Biobank might facilitate the Nottingham group’s further investigation into the role of polymorphic variants of uPAR in lung function decline.
Use the order calculator below and get started! Contact our live support team for any assistance or inquiry.
[order_calculator]