Bovine spongiform encephalopathy (BSE)

1. Explain the role of protein misfolding and aggregation in BS, including the following points:
• the name of the protein that is misfolding
• why the protein is misfolding
• why there is aggregation
• what structures the aggregated proteins form
• how this process leads to the symptoms of BSE
2. Explain the role of prions in BSE, including the following points:
• what a prion is
• the name of the prion in BSE
• how prions lead to the disease
3. Explain the role of the chaperone protein in BSE, including the following points:
• how chaperones normally act in the cell
• the name of the specific protein that acts as a chaperone in BSE
• how the protein that acts as a chaperone is different from typical chaperone proteins
4. Recommend ways that a country that does not have regulations in place can decrease the risk of BSE infecting the food source, based on your understanding of BSE and how it spreads (e.g., feeding practices, animal disposal)

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